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Phenotypes Associated with This Genotype
Genotype
MGI:3577344
Allelic
Composition
inad/inad
Genetic
Background
C57BL/6-inad
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
inad mutation (1 available); any inad mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cross section of brain of inad/inad mouse.

mortality/aging
• died usually 3-8 weeks after birth

nervous system
• neurodystrophic changes with numerous spheroid bodies in nervous tissues such as in the hippocampus, thalamus, hypothalamus, pons, callosal body, striatum, globus pallidus, and the cervical, thoracic and lumbar vertebrae
• axonal dystrophic change represented by spheroid bodies in the gracile tract of the medulla oblongata
• hippocampus is hardly distinguishable due to its thinness and caudal displacement caused by ventricular enlargement

behavior/neurological
• when suspended by tail, the limbs become flexed and then fold toward the trunk compared to controls in which limbs are held extended out from the trunk
• sensory ataxia
• dragging of hindlimbs
• progressive motor paralysis and atrophy of the hindlimbs, which show muscle weakness with foot-droop

limbs/digits/tail
• initially mutants exhibit an abnormal limb posture and later show atrophy of the hindlimbs

adipose tissue
• lean body, particularly in the lower half

Mouse Models of Human Disease
OMIM ID Ref(s)
Neurodegeneration with Brain Iron Accumulation 2A; NBIA2A 256600 J:97670


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory