Phenotypes Associated with This Genotype

Genotype
MGI:3577312

• Allelic Composition: Mmp11^tm1Mrio/Mmp11^tm1Mrio; Tg(MMTV-vHaras)SH1Led/Tg(MMTV-vHaras)SH1Led
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J * CD-1 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:86074 )

• all mutants developed mammary gland tumors however the average age of tumor onset was 37 weeks compared to 25 weeks in control transgenic mice that are wildtype for Mmp11

• mean time required to develop detectable tumor after the first pregnancy was about 10 weeks longer than in control transgenic mice that are wildtype for Mmp11

• decreased invasive primary tumor incidence compared to control transgenic mice that are wildtype for Mmp11

increased metastatic potential ( J:86074 )

• 69% developed lung metastases compared to 31% of control transgenic mice that are wildtype for Mmp11

• higher total number of metastases compared to transgenic mice that are wildtype for Mmp11

decreased tumor growth/size ( J:86074 )

• mean tumor number per mouse was about 40% lower than in control transgenic mice that are wildtype for Mmp11

• mean total tumor volume was about 2-fold lower than in control transgenic mice that are wildtype for Mmp11

increased carcinoma incidence ( J:86074 )

• developed tumors of various sizes that corresponded to moderately to poorly differentiated invasive duct carcinomas with most tumors growing as solid areas that contained no stroma

integument

increased mammary gland tumor incidence ( J:86074 )

• all mutants developed mammary gland tumors however the average age of tumor onset was 37 weeks compared to 25 weeks in control transgenic mice that are wildtype for Mmp11

• mean time required to develop detectable tumor after the first pregnancy was about 10 weeks longer than in control transgenic mice that are wildtype for Mmp11

• decreased invasive primary tumor incidence compared to control transgenic mice that are wildtype for Mmp11

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:86074 )

• all mutants developed mammary gland tumors however the average age of tumor onset was 37 weeks compared to 25 weeks in control transgenic mice that are wildtype for Mmp11

• mean time required to develop detectable tumor after the first pregnancy was about 10 weeks longer than in control transgenic mice that are wildtype for Mmp11

• decreased invasive primary tumor incidence compared to control transgenic mice that are wildtype for Mmp11