Phenotypes Associated with This Genotype

Genotype
MGI:3577255

• Allelic Composition: Drd2^tm1Mok/Drd2^tm1Mok
• Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

enlarged pituitary intermediate lobe ( J:97838 )

• the intermediate lobe is enlarged; however the anterior lobe is normal

abnormal single cell response ( J:97838 )

• in mutant neurons from the substantia nigra compacta 100 um dopamine had no effect on membrane potentials unlike in wild-type neurons where dopamine inhibited spontaneous firing

pigmentation

darkened coat color ( J:97838 )

• agouti coat color is darker with the back darker than other regions of the body

endocrine/exocrine glands

enlarged pituitary intermediate lobe ( J:97838 )

• the intermediate lobe is enlarged; however the anterior lobe is normal

homeostasis/metabolism

abnormal circulating hormone level ( J:97838 )

• alpha-melanocyte stimulating hormone levels are elevated about 15-fold compared to wild-type mice

increased pituitary hormone level ( J:97838 )

• levels of pro-opiomelanocortin are increased in the pituitary; however, levels of prolactin are normal

integument

darkened coat color ( J:97838 )

• agouti coat color is darker with the back darker than other regions of the body