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Phenotypes Associated with This Genotype
Genotype
MGI:3577096
Allelic
Composition
Tg(MMTVneu)202Mul/0
Genetic
Background
FVB/N-Tg(MMTVneu)202Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVneu)202Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 50% incidence observed in both virgin and non-virgin females by 205 days of age; males appear phenotypically normal
• focal adenocarcinomas surrounded by hyperplastic mammary epithelium
• 72% of the tumor-bearing mice that lived to an age of 8 months or older developed metastases to the lung
• multiple foci of metastatic mammary adenocarcinoma lodged in pulmonary vessels were observed

integument
• 50% incidence observed in both virgin and non-virgin females by 205 days of age; males appear phenotypically normal
• focal adenocarcinomas surrounded by hyperplastic mammary epithelium

endocrine/exocrine glands
• 50% incidence observed in both virgin and non-virgin females by 205 days of age; males appear phenotypically normal
• focal adenocarcinomas surrounded by hyperplastic mammary epithelium

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:56332


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory