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Phenotypes Associated with This Genotype
Genotype
MGI:3576767
Allelic
Composition
Tg(Cryaa-TAg)1Ove/0
Tg(Ins2-CALM1)26Ove/0
Genetic
Background
FVB(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cryaa-TAg)1Ove mutation (1 available)
Tg(Ins2-CALM1)26Ove mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• reduced pancreatic insulin levels; early onset and increased severity with age
• pancreatic insulin content was 28% of control levels
• insulin mRNA levels were also reduced
• elevated serum glucagon levels
• markedly lower serum insulin levels

renal/urinary system

endocrine/exocrine glands
• the number of beta cells per islet was reduced
• reduced pancreatic insulin levels; early onset and increased severity with age
• pancreatic insulin content was 28% of control levels
• insulin mRNA levels were also reduced

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:97926


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory