Mouse Genome Informatics
cx
    Tg(Cryaa-TAg)1Ove/0
Tg(Ins2-CALM1)26Ove/0

FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• reduced pancreatic insulin levels; early onset and increased severity with age
• pancreatic insulin content was 28% of control levels
• insulin mRNA levels were also reduced
• elevated serum glucagon levels
• markedly lower serum insulin levels

renal/urinary system

endocrine/exocrine glands
• the number of beta cells per islet was reduced
• reduced pancreatic insulin levels; early onset and increased severity with age
• pancreatic insulin content was 28% of control levels
• insulin mRNA levels were also reduced

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:97926