Phenotypes Associated with This Genotype

Genotype
MGI:3576651

• Allelic Composition: Minute/Minute⁺
• Genetic Background: involves: 101/H * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:65007 )

• most postnatal lethality of mice with a paternal allele occurres around P4

• Background Sensitivity: survival is enhanced in M. m. castaneus cross

cellular

abnormal imprinting ( J:65007 )

• abnormal imprinting of Igf2 occurs with mice receiving the maternal allele having increased growth rates in utero while mice receiving the paternal allele having decreased in utero growth rates

embryo

embryonic growth retardation ( J:65007 )

• severe growth retardation is seen at E13 through birth in mice inheriting a paternal allele

abnormal placenta weight ( J:65007 )

• placental weight ratios are more severely reduced than fetal weight ratios with mice inheriting a paternal allele

craniofacial

abnormal head shape ( J:65007 )

• mice inheriting a paternal allele exhibit a domed head phenotype

growth/size/body

abnormal head shape ( J:65007 )

• mice inheriting a paternal allele exhibit a domed head phenotype

embryonic growth retardation ( J:65007 )

• severe growth retardation is seen at E13 through birth in mice inheriting a paternal allele

decreased birth body size ( J:65007 )

• at birth, size of mice inheriting a paternal allele is less than 50% of normal

decreased body weight ( J:65007 )

• adults with a paternal allele are only about 60% of the weight of wild-type littermates

postnatal growth retardation ( J:65007 )

• postnatal growth is also reduced in mice inheriting a paternal allele, with weight reaching a minimum at about 4 days of age

• adults with a paternal allele are only about 60% of the weight of wild-type littermates

fetal growth retardation ( J:65007 )

• severe growth retardation is seen at E13 through birth in mice inheriting a paternal allele