Mouse Genome Informatics
hm
    Airetm1Mmat/Airetm1Mmat
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• developed autoimmunity against the defined target antigen, spectrin alpha 2 (alpha-fodrin), a ubiquitously expressed actin binding protein

endocrine/exocrine glands
N
• developed Sjogren's syndrome-like pathologic changes in the exocrine organs (J:96580)
• infiltration of many lymphoid cells in the parotid glands
• infiltration of many lymphoid cells in the submandibular glands
• infiltration of many lymphoid cells in the lacrimal glands
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas
• secretion of tears per unit of mouse body weight was decreased

vision/eye
• infiltration of many lymphoid cells in the lacrimal glands
• secretion of tears per unit of mouse body weight was decreased

reproductive system
• homozygous crossings produced offspring only occasionally

digestive/alimentary system
• infiltration of many lymphoid cells in the parotid glands
• infiltration of many lymphoid cells in the submandibular glands
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas

Mouse Models of Human Disease
OMIM IDRef(s)
Autoimmune Polyendocrine Syndrome, Type I, with or without Reversible Metaphyseal Dysplasia; APS1 240300 J:96580
Sjogren Syndrome 270150 J:96580