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Phenotypes Associated with This Genotype
Genotype
MGI:3576479
Allelic
Composition
Airetm1Mmat/Airetm1Mmat
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1Mmat mutation (0 available); any Aire mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• infiltration of many lymphoid cells in the parotid glands
• infiltration of many lymphoid cells in the submandibular glands
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas
• infiltration of many lymphoid cells in the lacrimal glands
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas
• developed autoimmunity against the defined target antigen, spectrin alpha 2 (alpha-fodrin), a ubiquitously expressed actin binding protein

endocrine/exocrine glands
N
• developed Sjogren's syndrome-like pathologic changes in the exocrine organs
• infiltration of many lymphoid cells in the parotid glands
• infiltration of many lymphoid cells in the submandibular glands
• infiltration of many lymphoid cells in the lacrimal glands
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas

vision/eye
• infiltration of many lymphoid cells in the lacrimal glands
• secretion of tears per unit of mouse body weight was decreased

reproductive system
• homozygous crossings produced offspring only occasionally

digestive/alimentary system
• infiltration of many lymphoid cells in the parotid glands
• infiltration of many lymphoid cells in the submandibular glands
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory