About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3576479
Allelic
Composition
Airetm1Mmat/Airetm1Mmat
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1Mmat mutation (0 available); any Aire mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• infiltration of many lymphoid cells in the parotid glands (J:96580)
• infiltration of many lymphoid cells in the parotid glands (J:96580)
• infiltration of many lymphoid cells in the submandibular glands (J:96580)
• infiltration of many lymphoid cells in the submandibular glands (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)
• infiltration of many lymphoid cells in the lacrimal glands (J:96580)
• infiltration of many lymphoid cells in the lacrimal glands (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)
• developed autoimmunity against the defined target antigen, spectrin alpha 2 (alpha-fodrin), a ubiquitously expressed actin binding protein (J:96580)
• developed autoimmunity against the defined target antigen, spectrin alpha 2 (alpha-fodrin), a ubiquitously expressed actin binding protein (J:96580)

endocrine/exocrine glands
N
• developed Sjogren's syndrome-like pathologic changes in the exocrine organs (J:96580)
• developed Sjogren's syndrome-like pathologic changes in the exocrine organs (J:96580)
• infiltration of many lymphoid cells in the parotid glands (J:96580)
• infiltration of many lymphoid cells in the parotid glands (J:96580)
• infiltration of many lymphoid cells in the submandibular glands (J:96580)
• infiltration of many lymphoid cells in the submandibular glands (J:96580)
• infiltration of many lymphoid cells in the lacrimal glands (J:96580)
• infiltration of many lymphoid cells in the lacrimal glands (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)

vision/eye
• infiltration of many lymphoid cells in the lacrimal glands (J:96580)
• infiltration of many lymphoid cells in the lacrimal glands (J:96580)
• secretion of tears per unit of mouse body weight was decreased (J:96580)
• secretion of tears per unit of mouse body weight was decreased (J:96580)

reproductive system
• homozygous crossings produced offspring only occasionally (J:96580)
• homozygous crossings produced offspring only occasionally (J:96580)

digestive/alimentary system
• infiltration of many lymphoid cells in the parotid glands (J:96580)
• infiltration of many lymphoid cells in the parotid glands (J:96580)
• infiltration of many lymphoid cells in the submandibular glands (J:96580)
• infiltration of many lymphoid cells in the submandibular glands (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory