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Phenotypes Associated with This Genotype
Genotype
MGI:3576471
Allelic
Composition
Prg4tm1Mawa/Prg4tm1Mawa
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prg4tm1Mawa mutation (1 available); any Prg4 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Prg4tm1Mawa/Prg4tm1Mawa mice develop joint disease with increasing age

skeleton
• by 2 months of age, irregular endochondral growth plates are seen
• by 2 months of age, joint cartilage displays proteinaceous deposits on the cartilage surface
• by 9 months of age, the articular cartilage surface in the knee is barely recognizable
• by 2 months of age, synovial hyperplasia, subintimal fibrosis, proteinaceous deposits on the cartilage surface, and irregular endochondral growth plates are seen
• by 9 months of age, calcification is seen in structures flanking the ankle joints
• by 4 months of age swelling of the tarsal joints is seen
• by 9 months of age, the knee joint space is filled by noninflammatory, hyperplastic synovium
• synovial hyperplasis is first seen at 2 weeks of age, progresses with age, and is the result of increased cell proliferation not decreased cell death

behavior/neurological
• by 4 months of age mutants develop a hopping gait

limbs/digits/tail
• by 4 months of age flexion deformity of the hind paws is seen

cardiovascular system
N
• no signs of pericardial overgrowth are seen unlike in human patients with Arthropathy-Camptodactyly Syndrome


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory