Mouse Genome Informatics
hm
    Prg4tm1Mawa/Prg4tm1Mawa
involves: 129S/SvEv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Prg4tm1Mawa/Prg4tm1Mawa mice develop joint disease with increasing age

skeleton
• by 2 months of age, irregular endochondral growth plates are seen
• by 2 months of age, joint cartilage displays proteinaceous deposits on the cartilage surface
• by 9 months of age, the articular cartilage surface in the knee is barely recognizable
• by 2 months of age, synovial hyperplasia, subintimal fibrosis, proteinaceous deposits on the cartilage surface, and irregular endochondral growth plates are seen
• by 9 months of age, calcification is seen in structures flanking the ankle joints
• by 4 months of age swelling of the tarsal joints is seen
• by 9 months of age, the knee joint space is filled by noninflammatory, hyperplastic synovium
• synovial hyperplasis is first seen at 2 weeks of age, progresses with age, and is the result of increased cell proliferation not decreased cell death

behavior/neurological
• by 4 months of age mutants develop a hopping gait

limbs/digits/tail
• by 4 months of age flexion deformity of the hind paws is seen

cardiovascular system
N
• no signs of pericardial overgrowth are seen unlike in human patients with Arthropathy-Camptodactyly Syndrome (J:96756)

Mouse Models of Human Disease
OMIM IDRef(s)
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome; CACP 208250 J:96756