Phenotypes Associated with This Genotype

Genotype
MGI:3576286

• Allelic Composition: Drd2^tm1Yyw/Drd2^tm1Yyw
• Genetic Background: B6.129S4-Drd2^tm1Yyw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavioral response to xenobiotic ( J:65770 , J:82829 )

• decreased haloperidol-induced catalepsy and inhibition of locomotion and rearing are seen compared to wild-type littermates (J:65770)

• D-amphetamine induced a different pattern of stereotypic behaviors in mutant mice compared to wild-type littermates (J:82829)

• apomorphine (a dopamine agonist) induced increased biting behavior but reduced climbing compared to wild-type mice (J:82829)

• co-administration of DRD1 and DRD2 agonists induces significantly more biting and less climbing behaviors compared to wild-type littermates (J:82829)

decreased anxiety-related response ( J:65770 )

• in an elevated zero-maze mutants spend less time in stretched attend postures

decreased vertical activity ( J:65770 )

decreased locomotor activity ( J:65770 )

• activity is reduced in an open field test and during both the diurnal and nocturnal periods when mutants were monitored in their home cages; however, circadian rhythms are normal

• fertility, body weight, coat color, and neuroanatomy are all normal