Phenotypes Associated with This Genotype

Genotype
MGI:3576285

• Allelic Composition: Drd2^tm1Yyw/Drd2^tm1Yyw
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to xenobiotic ( J:65770 )

• decreased haloperidol-induced catalepsy is seen compared to wild-type littermates

decreased anxiety-related response ( J:65770 )

• in an elevated zero-maze mutants spend less time in stretched attend postures

decreased vertical activity ( J:65770 )

decreased locomotor activity ( J:65770 )

• activity is reduced in an open field test

• fertility, body weight, coat color, and neuroanatomy are all normal

bradykinesia ( J:65770 )

• prolonged immobility is seen in the ring test compared to wild-type littermates

• this phenotype is only significant in the mixed background and not in mutants backcrossed to C57BL/6 for 5 generations