Phenotypes for Atrn MGI:3575834 MGI Mouse

abnormal coat/hair pigmentation ( J:71075 )

• reduced levels of pheomelanin and 20-30% reductions in eumelanin between 5 and 11 months of age

• lacks yellow bands in hair

darkened coat color ( J:81466 , J:96070 )

• yellow pigment is completely absent resulting in a black coat (J:81466)

• mahogany coat (J:96070)

seizures ( J:96070 )

• observed in a few mutants, characterized by a sudden freezing of motion followed by toppling over onto the side and did not progress to tonic-clonic convulsive activity

abnormal brain morphology ( J:80364 )

brain vacuoles ( J:71075 , J:81466 , J:96070 )

• vacuoles in all regions of the CNS by 1 month of age (J:71075)

• vacuolation becomes exaggerated with increasing age (J:71075)

• most vacuoles in the gray matter of 6-month old mutants are membrane bound, not enclosed by myelin sheaths, and appear to originate from dendrites or astrocytic processes (J:81466)

• vacuoles in the brain (J:96070)

astrocytosis ( J:81466 )

• by 11 to 12 months of age, many brain regions exhibit moderate to severe astrocytosis

spongiform encephalopathy ( J:81466 )

• age-dependent progression of spongiform degeneration

postnatal growth retardation ( J:71075 )

• males weigh 10-15% less than controls by 3 months of age

• female weights are not significantly lower than controls until 4 months of age

decreased total body fat amount ( J:71075 )

• 20-40% reduction in body fat

tremors ( J:96070 )

increased locomotor activity ( J:71075 )

• nocturnal locomotor activity is elevated 20-30%