Phenotypes Associated with This Genotype

Genotype
MGI:3575674

• Allelic Composition: Ppard^tm1Wwah/Ppard⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

delayed wound healing ( J:71272 )

• delay in wound healing throughout the whole repair process, with final closure postponed by 2-3 days, however skin elasticity was not impaired

• number of keratinocytes per surface unit is slightly higher at the edges of the skin wound

• cultured keratinocytes at the edges of a scrape wound detached more readily and exhibited a slower migration rate than wildtype

integument

abnormal keratinocyte adhesion ( J:71272 )

• isolated keratinoctyes are rounded and only adhered 4 days after seeding compared to controls that adhered and spread 24 hours after seeding

increased keratinocyte proliferation ( J:71272 )

• slight but significant increase in keratinocyte proliferation rate, however hair follicle cycle was normal

• increased keratinocyte proliferative response to tetradecanoylphorbol acetate (TPA) stimulation on the dorsal epidermis and in response to hair plucking of the dorsal skin

thick epidermis ( J:71272 )

• slight but significant increase in epidermal thickness, however no defect in epidermal differentiation

cellular

abnormal keratinocyte adhesion ( J:71272 )

• isolated keratinoctyes are rounded and only adhered 4 days after seeding compared to controls that adhered and spread 24 hours after seeding

increased keratinocyte proliferation ( J:71272 )

• slight but significant increase in keratinocyte proliferation rate, however hair follicle cycle was normal

• increased keratinocyte proliferative response to tetradecanoylphorbol acetate (TPA) stimulation on the dorsal epidermis and in response to hair plucking of the dorsal skin