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Phenotypes Associated with This Genotype
Genotype
MGI:3575660
Allelic
Composition
Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmo4tm1.1Gng mutation (0 available); any Lmo4 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryonic lethality increased progressively with time from E10.5 to birth

embryo
• varied penetrance of growth retardation with some mutants that where small at E10.5 and others that were normal in size
• failure of neural fold elevation and folding resulting in the failure of neural tube closure between the caudal border of the forebrain and the rostral border of the hindbrain
• increased apoptosis at E10.5 and abnormal patterns of cell proliferation in the ventral neuroepithelium that everts rather than elevates
• ventral neuroepithelium everts rather than elevates
• failure of neural tube closure between the caudal border of the forebrain and the rostral border of the hindbrain

growth/size/body
• varied penetrance of growth retardation with some mutants that where small at E10.5 and others that were normal in size

nervous system
• increased apoptosis at E10.5 and abnormal patterns of cell proliferation in the ventral neuroepithelium that everts rather than elevates
• ventral neuroepithelium everts rather than elevates
• failure of neural tube closure between the caudal border of the forebrain and the rostral border of the hindbrain
• varied phenotypic penetrance with some mutants exhibiting exencephaly at early times (E9.5 to E14.5) and others having normal skull closure (J:96957)
• 55% show exencephaly (J:114626)
• abnormal patterns of cell proliferation in the ventral neuroepithelium at E10.5
• increased apoptosis at E10.5 in the ventral neuroepithelium

vision/eye
• 16% exhibit open eyes at birth

Mouse Models of Human Disease
OMIM ID Ref(s)
Anencephaly 206500 J:96957


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory