Mouse Genome Informatics
hm
    Lmo4tm1.1Gng/Lmo4tm1.1Gng
involves: 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• embryonic lethality increased progressively with time from E10.5 to birth

embryogenesis
• varied penetrance of growth retardation with some mutants that where small at E10.5 and others that were normal in size
• failure of neural fold elevation and folding resulting in the failure of neural tube closure between the caudal border of the forebrain and the rostral border of the hindbrain
• increased apoptosis at E10.5 and abnormal patterns of cell proliferation in the ventral neuroepithelium that everts rather than elevates
• ventral neuroepithelium everts rather than elevates
• failure of neural tube closure between the caudal border of the forebrain and the rostral border of the hindbrain

growth/size/body
• varied penetrance of growth retardation with some mutants that where small at E10.5 and others that were normal in size

nervous system
• increased apoptosis at E10.5 and abnormal patterns of cell proliferation in the ventral neuroepithelium that everts rather than elevates
• ventral neuroepithelium everts rather than elevates
• failure of neural tube closure between the caudal border of the forebrain and the rostral border of the hindbrain
• varied phenotypic penetrance with some mutants exhibiting exencephaly at early times (E9.5 to E14.5) and others having normal skull closure (J:96957)
• 55% show exencephaly (J:114626)
• abnormal patterns of cell proliferation in the ventral neuroepithelium at E10.5
• increased apoptosis at E10.5 in the ventral neuroepithelium

vision/eye
• 16% exhibit open eyes at birth

Mouse Models of Human Disease
OMIM IDRef(s)
Anencephaly 206500 J:96957