Phenotypes Associated with This Genotype

Genotype
MGI:3575525

• Allelic Composition: Folr1^tm1Fnn/Folr1⁺
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:96380 )

• 38 weeks after treatment with azoxymethane, about 4-fold more focal inflammatory lesions are seen and 5 out of 10 treated heterozygotes developed adenocarcinomas compared to 3 out of 11 wild-type mice

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:96380 )

• the number of colonic cells per crypt column is increased

homeostasis/metabolism

abnormal folic acid level ( J:96380 )

• the level of folate in the plasma and colonic mucosa is decreased compared to wild-type littermates

increased physiological sensitivity to xenobiotic ( J:96380 )

• 38 weeks after treatment with azoxymethane, about 4-fold more focal inflammatory lesions are seen

increased incidence of tumors by chemical induction ( J:96380 )

• 38 weeks after treatment with azoxymethane, about 4-fold more focal inflammatory lesions are seen and 5 out of 10 treated heterozygotes developed adenocarcinomas compared to 3 out of 11 wild-type mice

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:96380 )

• the number of colonic cells per crypt column is increased