Phenotypes Associated with This Genotype

Genotype
MGI:3575509

• Allelic Composition: Rap1b^tm1Gwht/Rap1b^tm1Gwht
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:96758 )

• 40% of homozygous embryos begin to die around E13.5

perinatal lethality, incomplete penetrance ( J:96758 )

• about 55% of homozygous embryos die perinatally

postnatal lethality, incomplete penetrance ( J:96758 )

• in heterozygous crosses only 4.4% of pups at weaning are homozygous

cardiovascular system

hemorrhage ( J:96758 )

• 40% of homozygous embryos had abdominal, cranial, and hepatic bleeding

growth/size/body

decreased body size ( J:96758 )

• surviving homozygotes are smaller than their littermates

hematopoietic system

decreased platelet aggregation ( J:96758 )

• platelet aggregation in response to collagen, convulxin (snake venom), an F2RL3 activating peptide, or a calcium ionophore (A23187) is reduced

• however, similar to wild-type, P2RY1 and P2RY12 antagonists can block aggregation

reproductive system

decreased litter size ( J:96758 )

• crosses between surviving homozygotes produce 45% smaller litters at weaning; however more homozygous pups survive compared to heterozygous crosses

homeostasis/metabolism

decreased platelet aggregation ( J:96758 )

• platelet aggregation in response to collagen, convulxin (snake venom), an F2RL3 activating peptide, or a calcium ionophore (A23187) is reduced

• however, similar to wild-type, P2RY1 and P2RY12 antagonists can block aggregation

decreased susceptibility to induced thrombosis ( J:96758 )

• homozygotes begin to form thrombi in a platelet-dependent carotid artery thrombosis model however vessel occlusion is not seen

increased bleeding time ( J:96758 )