Phenotypes Associated with This Genotype

Genotype
MGI:3575507

• Allelic Composition: Ucp1^tm1Kz/Ucp1^tm1Kz
• Genetic Background: (129S1.Cg-Ucp^tm1Kz x B6.Cg-Ucp^tm1Kz)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial physiology ( J:69573 )

• mitochondria exhibit an impaired response to free fatty acid-induced decoupling to a de-energized state; linoleic acid, lauric acid and stearic acid stimulation of mitochondria showed reduced rates of de-energization compared to controls as measured by protonmotive force and oxygen consumption

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:69573 )

N • maintained normal body temperature upon exposure to cold