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Phenotypes Associated with This Genotype
Genotype
MGI:3575503
Allelic
Composition		 Osmtm1Ymo/Osmtm1Ymo
Genetic
Background		 B6.Cg-Osmtm1Ymo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osmtm1Ymo mutation (0 available); any Osm mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
hypoalgesia ( J:97000 )
• displayed reduced noxious responses in models of acute thermal, mechanical, chemical, and visceral pain

nervous system
abnormal dorsal root ganglion morphology ( J:97000 )
• in the DRGs, vanilloid receptor 1 (VR1)- and P2x3-positive small-sized neurons were decreased
• OSMR-positive neurons are also decreased, resulting in the reduced number of VR1/P2X3/OSMR-triple positive neurons

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory