Phenotypes Associated with This Genotype

Genotype
MGI:3575000

• Allelic Composition: Pou4f2^tm1(ALPP)Whk/Pou4f2^tm2Whk
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased retina apoptosis ( J:96926 )

• at E15.5 retinal ganglion cell apoptosis is seen and at E17.5 loss of these cells is accelerated and propagated from the central to the peripheral retina

retina ganglion cell degeneration ( J:96926 )

• a loss of 70% of the retinal ganglion cells in the retinal ganglion cell layer is seen at 6 weeks of age

abnormal optic nerve morphology ( J:96926 )

• fewer and less fasciculated axon bundles projecting into the optic disc

• the cross-sectional area of the optic nerve is reduced

• an increased proportion of the axons project into the ipsilateral optic track or into the optic nerve of the opposite eye

abnormal optic nerve innervation ( J:134978 )

• retinal ganglion axons fail to reach the midline at E13.5

• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles

• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup

nervous system

retina ganglion cell degeneration ( J:96926 )

• a loss of 70% of the retinal ganglion cells in the retinal ganglion cell layer is seen at 6 weeks of age

abnormal optic nerve morphology ( J:96926 )

• fewer and less fasciculated axon bundles projecting into the optic disc

• the cross-sectional area of the optic nerve is reduced

• an increased proportion of the axons project into the ipsilateral optic track or into the optic nerve of the opposite eye

abnormal optic nerve innervation ( J:134978 )

• retinal ganglion axons fail to reach the midline at E13.5

• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles

• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup

cellular

increased retina apoptosis ( J:96926 )

• at E15.5 retinal ganglion cell apoptosis is seen and at E17.5 loss of these cells is accelerated and propagated from the central to the peripheral retina