Phenotypes Associated with This Genotype

Genotype
MGI:3574977

• Allelic Composition: Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr; Bmpr1b^tm1Kml/Bmpr1b^tm1Kml; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal retina pigment epithelium morphology ( J:96964 )

• at E12.5 the margin of the pigment epithelium is rough and a ventral discontinuity of the pigment is seen

vision/eye

increased retina apoptosis ( J:96964 )

• beginning at E11.25-E11.50 excess apoptosis is seen throughout the retina

abnormal eye development ( J:96964 )

• around E11.5 a drastic reduction in cell proliferation is seen in the retina

• Atoh7 expression is not initiated at E11.5 suggesting a failure to initiate retinal neurogenesis

abnormal retina morphology ( J:96964 )

• beginning at E11.25-E11.50 the retinal neuroectoderm is thinner

abnormal retina pigment epithelium morphology ( J:96964 )

• at E12.5 the margin of the pigment epithelium is rough and a ventral discontinuity of the pigment is seen

anophthalmia ( J:96964 )

• eyes are small at E12.5 and absent at birth

cellular

increased retina apoptosis ( J:96964 )

• beginning at E11.25-E11.50 excess apoptosis is seen throughout the retina