Mouse Genome Informatics
hm
    Mthfrtm1Rzn/Mthfrtm1Rzn
involves: 129S1/Sv * 129X1/SvJ * BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• 76.4% survived past 5 weeks of age

growth/size/body
• slower development than normal

homeostasis/metabolism
• lipid accumulation in the aorta near the aortic valve but no foam cells
• some microvesicular steatosis in the liver

limbs/digits/tail
• sometimes

reproductive system
• delayed maturation of external genitalia but generally fertile

skeleton
• occasionally

vision/eye
• among other facial anomalies

nervous system
• intermingled with granule cells rather than forming a discrete layer
• as determined in sagittal sections

integument
• delayed about 5 days in appearance

Mouse Models of Human Disease
OMIM IDRef(s)
Homocysteinemia 603174 J:67779
Neural Tube Defects, Folate-Sensitive 601634 J:67779