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Phenotypes Associated with This Genotype
Genotype
MGI:3574961
Allelic
Composition
Mthfrtm1Rzn/Mthfrtm1Rzn
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mthfrtm1Rzn mutation (2 available); any Mthfr mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 76.4% survived past 5 weeks of age

growth/size/body
• slower development than normal

homeostasis/metabolism
• lipid accumulation in the aorta near the aortic valve but no foam cells
• some microvesicular steatosis in the liver

limbs/digits/tail
• sometimes

reproductive system
• delayed maturation of external genitalia but generally fertile

skeleton
• occasionally

vision/eye
• among other facial anomalies

nervous system
• intermingled with granule cells rather than forming a discrete layer
• as determined in sagittal sections

integument
• delayed about 5 days in appearance


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory