About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3574961
Allelic
Composition
Mthfrtm1Rzn/Mthfrtm1Rzn
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mthfrtm1Rzn mutation (2 available); any Mthfr mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 76.4% survived past 5 weeks of age (J:67779)
• 76.4% survived past 5 weeks of age (J:67779)

growth/size/body
• slower development than normal (J:67779)
• slower development than normal (J:67779)

homeostasis/metabolism
• lipid accumulation in the aorta near the aortic valve but no foam cells (J:67779)
• some microvesicular steatosis in the liver (J:67779)
• lipid accumulation in the aorta near the aortic valve but no foam cells (J:67779)
• some microvesicular steatosis in the liver (J:67779)

limbs/digits/tail
• sometimes (J:67779)
• sometimes (J:67779)

reproductive system
• delayed maturation of external genitalia but generally fertile (J:67779)
• delayed maturation of external genitalia but generally fertile (J:67779)

skeleton
• occasionally (J:67779)
• occasionally (J:67779)

vision/eye
• among other facial anomalies (J:67779)
• among other facial anomalies (J:67779)

nervous system
• intermingled with granule cells rather than forming a discrete layer (J:67779)
• intermingled with granule cells rather than forming a discrete layer (J:67779)
• diffuse (J:67779)
• diffuse (J:67779)
• as determined in sagittal sections (J:67779)
• as determined in sagittal sections (J:67779)

integument
• delayed about 5 days in appearance (J:67779)
• delayed about 5 days in appearance (J:67779)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory