Phenotypes Associated with This Genotype

Genotype
MGI:3574820

• Allelic Composition: Fyn^tm1Sor/Fyn^tm1Sor; Yes1^tm1Sor/Yes1^tm1Sor
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:20346 )

• incomplete penetrance; only 35% of animals survived to weaning age; normal Mendelian ratios were present at E18.5

growth/size/body

decreased body size ( J:20346 )

• animals were described as smaller at weaning age

weight loss ( J:20346 )

• at 3-5 months of age, surviving animals began to lose weight

enlarged spleen ( J:20346 )

• due to prominent myeloid hyperplasia and expansion of the white pulp

hematopoietic system

enlarged spleen ( J:20346 )

• due to prominent myeloid hyperplasia and expansion of the white pulp

myeloid hyperplasia ( J:20346 )

extramedullary hematopoiesis ( J:20346 )

increased spleen white pulp amount ( J:20346 )

• expansion of the white pulp

homeostasis/metabolism

increased urine protein level ( J:20346 )

• greater than 100mg/dl with presence of leukocytes and erythrocytes in the urine

immune system

enlarged spleen ( J:20346 )

• due to prominent myeloid hyperplasia and expansion of the white pulp

myeloid hyperplasia ( J:20346 )

increased spleen white pulp amount ( J:20346 )

• expansion of the white pulp

renal/urinary system

increased urine protein level ( J:20346 )

• greater than 100mg/dl with presence of leukocytes and erythrocytes in the urine

abnormal kidney morphology ( J:20346 )

• pale with pitted surface

abnormal renal glomerulus morphology ( J:20346 )

• expanded mesangial matrix with paramesangial deposits

• diffuse mesangial hypercellularity in focal glomeruli

cortical renal glomerulopathies ( J:20346 )

• evident at 5 weeks of age

glomerulosclerosis ( J:20346 )

• segmental glomerulosclerosis

small kidney ( J:20346 )

• described as shrunken

abnormal renal tubule morphology ( J:20346 )

• renal interstitium displayed tubal ectasia and chronic inflammatory cell infiltrate with IgG, IgM, IgA and complement C3 deposits in the mesangium, but no evidence of autoimmune disease was observed

nervous system

abnormal hippocampus morphology ( J:20346 )

• undulations of the CA3 region; no more severe than in homozygous Fyn mutant mice

abnormal dentate gyrus morphology ( J:20346 )

• undulations; no more severe than in homozygous Fyn mutant mice

integument

ruffled hair ( J:20346 )

• observed at 3-5 months of age