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Phenotypes Associated with This Genotype
Genotype
MGI:3574646
Allelic
Composition		 Gdnftm2Bbd/Gdnf+
Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm2Bbd mutation (0 available); any Gdnf mutation (18 available)
Spry1tm1.1Jdli mutation (0 available); any Spry1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney development ( J:96485 )
• only 25% (4 of 16) mice exhibit abnormal kidney development versus about 92% (12 of 13) littermates homozygous Spry1tm1.1Jdli alone, indicating a ~75% reduction in the occurrence of kidney and urinary tract defects (CAKUT)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory