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Phenotypes Associated with This Genotype
Genotype
MGI:3574535
Allelic
Composition		 Dok1tm1Yyam/Dok1tm1Yyam
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell proliferation ( J:95641 )
• stimulation with intact antibodies to IgM induced proliferation in mutant but not wild-type B cells
decreased IgM level ( J:95641 )
• IgM levels are lower in mutants without stimulation and after stimulation with a T dependent antigen

hematopoietic system
increased B cell proliferation ( J:95641 )
• stimulation with intact antibodies to IgM induced proliferation in mutant but not wild-type B cells
decreased IgM level ( J:95641 )
• IgM levels are lower in mutants without stimulation and after stimulation with a T dependent antigen

cellular
increased B cell proliferation ( J:95641 )
• stimulation with intact antibodies to IgM induced proliferation in mutant but not wild-type B cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory