Phenotypes Associated with This Genotype

Genotype
MGI:3573950

• Allelic Composition: Zbtb7b^hd/Zbtb7b^hd
• Genetic Background: involves: 129/Sv * BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:48734 )

• thymic development of CD4 cells is abrogated, with the majority of single positive CD4+ thymocytes being immature CD4+8^low rather than CD4+8- cells and the absence of CD69- single-positive CD4+ thymocytes

absent CD4-positive, alpha-beta T cells ( J:48734 )

• lack peripheral single positive CD4+ T cells, however the total numbers of peripheral alpha-beta-TCR+ cells is the same as for wild-type

increased CD8-positive, alpha-beta T cell number ( J:48734 )

• elevated numbers of CD8+ alpha-beta-TCR+ T cells

immune system

abnormal CD4-positive T cell differentiation ( J:48734 )

• thymic development of CD4 cells is abrogated, with the majority of single positive CD4+ thymocytes being immature CD4+8^low rather than CD4+8- cells and the absence of CD69- single-positive CD4+ thymocytes

absent CD4-positive, alpha-beta T cells ( J:48734 )

• lack peripheral single positive CD4+ T cells, however the total numbers of peripheral alpha-beta-TCR+ cells is the same as for wild-type

increased CD8-positive, alpha-beta T cell number ( J:48734 )

• elevated numbers of CD8+ alpha-beta-TCR+ T cells

reproductive system

reduced female fertility ( J:48734 )

♀ • female infertility is impaired as intercrosses consistently produce small litters of 2-4 pups