Mouse Genome Informatics
ht
    Htttm1Detl/Htt+
involves: 129P2/OlaHsd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• during tail suspension, a similar % (<20%) of wild-type and heterozygous mutant mice tend to clasp (J:67074)
• at >40 weeks of age, heterozygotes show a late-onset increase in the average distance between front and hind paws ('overlap' distance) relative to wild-type mice
• heterozygotes are viable, fertile and developmentally normal; however, 1 out of 10 heterozygotes remains inactive upon removal of the cage lid whereas all wild-type mice show exploratory activity by walking around the cage

growth/size/body
• at 34 weeks of age, some heterozygotes exhibit an extreme size reduction relative to wild-type mice

homeostasis/metabolism
N
• heterozygotes display normal blood glucose levels relative to wild-type mice (J:67074)

nervous system
N
• heterozygotes display no extreme reductions in major brain regions up to 90 weeks of age (J:67074)
• no reactive gliosis or formation of neuronal intranuclear inclusions is observed (J:67074)

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:67074