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Phenotypes Associated with This Genotype
Genotype
MGI:3573788
Allelic
Composition
Nbntm1Nus/Nbntm2Nus
Tg(CD19-cre/ERT2)1Cgn/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm1Nus mutation (0 available); any Nbn mutation (40 available)
Nbntm2Nus mutation (0 available); any Nbn mutation (40 available)
Tg(CD19-cre/ERT2)1Cgn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• after 72 hours in culture only 39% of mutant B cells had completed 3 or more cell divisions, cells accumulated in the G2/M phase of the cell cycle, and relatively increased cell death is seen

immune system
• recombined B lymphocytes show increased spontaneous DNA damage, chromosomal aberrations including tetraploidy, and Ig class-switch recombination is diminished
• after 72 hours in culture only 39% of mutant B cells had completed 3 or more cell divisions, cells accumulated in the G2/M phase of the cell cycle, and relatively increased cell death is seen
• IgG, IgG1, IgG2b and IgG3 levels are reduced
• IgM levels are normal

hematopoietic system
• recombined B lymphocytes show increased spontaneous DNA damage, chromosomal aberrations including tetraploidy, and Ig class-switch recombination is diminished
• after 72 hours in culture only 39% of mutant B cells had completed 3 or more cell divisions, cells accumulated in the G2/M phase of the cell cycle, and relatively increased cell death is seen
• IgG, IgG1, IgG2b and IgG3 levels are reduced
• IgM levels are normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Nijmegen breakage syndrome DOID:7400 OMIM:251260
J:96102


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory