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Phenotypes Associated with This Genotype
Genotype
MGI:3573782
Allelic
Composition
Dmdtm1.1Khan/Y
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdtm1.1Khan mutation (0 available); any Dmd mutation (153 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• frequent muscle fiber necrosis peaking in 3-4 weeks old mice was observed
• severe muscular hypertrophy and dystrophy were observed in the skeletal muscle and diaphragm
• degenerating muscle fibers with cellular infiltration and regenerated muscle appeared at 4 weeks of age
• extensive myofiber degeneration in diaphragm muscle at 4 weeks of age

reproductive system
• hemizygous males were viable and normal in body size and external appearance, but they did not reproduced despite intensive mating

cellular
• frequent muscle fiber necrosis peaking in 3-4 weeks old mice was observed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Duchenne muscular dystrophy DOID:11723 OMIM:310200
J:96210


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory