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Phenotypes Associated with This Genotype
Genotype
MGI:3573782
Allelic
Composition
Dmdtm1.1Khan/Y
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdtm1.1Khan mutation (0 available); any Dmd mutation (135 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• severe muscular hypertrophy and dystrophy were observed in the skeletal muscle and diaphragm (J:96210)
• severe muscular hypertrophy and dystrophy were observed in the skeletal muscle and diaphragm (J:96210)
• degenerating muscle fibers with cellular infiltration and regenerated muscle appeared at 4 weeks of age (J:96210)
• extensive myofiber degeneration in diaphragm muscle at 4 weeks of age (J:96210)
• degenerating muscle fibers with cellular infiltration and regenerated muscle appeared at 4 weeks of age (J:96210)
• extensive myofiber degeneration in diaphragm muscle at 4 weeks of age (J:96210)
• frequent muscle fiber necrosis peaking in 3-4 weeks old mice was observed (J:96210)
• frequent muscle fiber necrosis peaking in 3-4 weeks old mice was observed (J:96210)

reproductive system
• hemizygous males were viable and normal in body size and external appearance, but they did not reproduced despite intensive mating (J:96210)
• hemizygous males were viable and normal in body size and external appearance, but they did not reproduced despite intensive mating (J:96210)

Mouse Models of Human Disease
OMIM ID Ref(s)
Muscular Dystrophy, Duchenne Type; DMD 310200 J:96210


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory