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Phenotypes Associated with This Genotype
Genotype
MGI:3531425
Allelic
Composition		 Aph1btm1Bdes/Aph1btm1Bdes
Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aph1btm1Bdes mutation (1 available); any Aph1b mutation (19 available)
Aph1ctm1.1Bdes mutation (0 available); any Aph1c mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:96106 )
• double homozygous null mice were viable and fertile and did not show any significant aberrations in the brain, kidney, or testis, however gamma-secretase activity in the brain stem, cerebellum, and the olfactory bulb was decreased

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory