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Phenotypes Associated with This Genotype
Genotype
MGI:3531405
Allelic
Composition
Phox2a/Inppl1tm1Ssch/Phox2a/Inppl1tm1Ssch
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2a/Inppl1tm1Ssch mutation (0 available); any Inppl1 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous mice die within 3 days after birth
• homozygous mice were transiently rescued for up to 96 h by repeated injection of D-glucose during the first 24 h postpartum or injection of neutralizing antibody to insulin within the first hour after birth

behavior/neurological
• homozygotes become lethargic after birth
• injection of D-glucose during the first 24 h postpartum increased activity

growth/size/body
• all homozygotes failed to gain weight

homeostasis/metabolism
• blood glucose levels are normal at 2-8 h after birth; however, hypoglycemia develops 10-15 h after birth
• homozygous mice show decreased expression of several key gluconeogenic enzymes, contributing to hypoglycemia
• injection with an anti-insulin antibody within the first hour after birth improved survival and increased glucose levels indicating increased insulin sensitivity

respiratory system
• homozygotes presented signs of respiratory distress; however, the cause of respiratory distress was not due to a lack of surfactant or an abnormal differentiation of surfactant-producing cell


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory