Mouse Genome Informatics
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
phenotype observed in females
phenotype observed in males
N normal phenotype
• homozygous mice die within 3 days after birth
• homozygous mice were transiently rescued for up to 96 h by repeated injection of D-glucose during the first 24 h postpartum or injection of neutralizing antibody to insulin within the first hour after birth

• homozygotes become lethargic after birth
• injection of D-glucose during the first 24 h postpartum increased activity

• all homozygotes failed to gain weight

• blood glucose levels are normal at 2-8 h after birth; however, hypoglycemia develops 10-15 h after birth
• homozygous mice show decreased expression of several key gluconeogenic enzymes, contributing to hypoglycemia
• injection with an anti-insulin antibody within the first hour after birth improved survival and increased glucose levels indicating increased insulin sensitivity

respiratory system
• homozygotes presented signs of respiratory distress; however, the cause of respiratory distress was not due to a lack of surfactant or an abnormal differentiation of surfactant-producing cell

Mouse Models of Human Disease
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:96443