Mouse Genome Informatics
hm
    Phox2a/Inppl1tm1Ssch/Phox2a/Inppl1tm1Ssch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• homozygous mice die within 3 days after birth
• homozygous mice were transiently rescued for up to 96 h by repeated injection of D-glucose during the first 24 h postpartum or injection of neutralizing antibody to insulin within the first hour after birth

behavior/neurological
• homozygotes become lethargic after birth
• injection of D-glucose during the first 24 h postpartum increased activity

growth/size/body
• all homozygotes failed to gain weight

homeostasis/metabolism
• blood glucose levels are normal at 2-8 h after birth; however, hypoglycemia develops 10-15 h after birth
• homozygous mice show decreased expression of several key gluconeogenic enzymes, contributing to hypoglycemia
• injection with an anti-insulin antibody within the first hour after birth improved survival and increased glucose levels indicating increased insulin sensitivity

respiratory system
• homozygotes presented signs of respiratory distress; however, the cause of respiratory distress was not due to a lack of surfactant or an abnormal differentiation of surfactant-producing cell

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:96443