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Phenotypes Associated with This Genotype
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2a/Inppl1tm1Ssch mutation (0 available); any Phox2a mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• homozygous mice die within 3 days after birth
• homozygous mice were transiently rescued for up to 96 h by repeated injection of D-glucose during the first 24 h postpartum or injection of neutralizing antibody to insulin within the first hour after birth

• homozygotes become lethargic after birth
• injection of D-glucose during the first 24 h postpartum increased activity

• all homozygotes failed to gain weight

• blood glucose levels are normal at 2-8 h after birth; however, hypoglycemia develops 10-15 h after birth
• homozygous mice show decreased expression of several key gluconeogenic enzymes, contributing to hypoglycemia
• injection with an anti-insulin antibody within the first hour after birth improved survival and increased glucose levels indicating increased insulin sensitivity

respiratory system
• homozygotes presented signs of respiratory distress; however, the cause of respiratory distress was not due to a lack of surfactant or an abnormal differentiation of surfactant-producing cell

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:96443

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory