Phenotypes Associated with This Genotype

Genotype
MGI:3531205

• Allelic Composition: Suz12^{Gt(Betageo)1Khe}/Suz12^{Gt(Betageo)1Khe}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:93307 )

• die during early postimplantation stages, with nearly complete reabsorption of embryos at E10.5 and much smaller embryos at E8.5

cellular

increased embryonic tissue cell apoptosis ( J:93307 )

• large number of cells in E7.5 embryos underwent cell death

decreased cell proliferation ( J:93307 )

• E7.5 and E8.5 embryonic cells fail to proliferate

embryo

increased embryonic tissue cell apoptosis ( J:93307 )

• large number of cells in E7.5 embryos underwent cell death

abnormal developmental patterning ( J:93307 )

• difficult to determine the distinction between the three embryonic sheets

embryonic growth arrest ( J:93307 )

• developmental block at around E7.5

decreased embryo size ( J:93307 )

• E7.5 and E8.5 homozygous embryos were severely reduced in size with the E8.5 embryos resembling E7.5 embryos

abnormal embryonic neuroepithelium morphology ( J:93307 )

• the neural ectoderm does not develop, resulting in the complete absence of organogenesis

abnormal extraembryonic tissue morphology ( J:93307 )

abnormal amnion morphology ( J:93307 )

• amnion was indistinguishable at E7.5

abnormal amniotic cavity morphology ( J:93307 )

• the amniotic cavity does not form correctly

• the amniotic cavity did not fold around the E8.5 embryo

abnormal chorion morphology ( J:93307 )

• chorion was indistinguishable at E7.5 and did not extend around the embryo at E8.5

abnormal ectoplacental cavity morphology ( J:93307 )

• the ectoplacental cavity does not form correctly and vacuolated cells were found in the region of the ectoplacental cavity

abnormal extraembryonic coelom morphology ( J:93307 )

• the exocoelomic cavity does not form correctly

growth/size/body

decreased embryo size ( J:93307 )

• E7.5 and E8.5 homozygous embryos were severely reduced in size with the E8.5 embryos resembling E7.5 embryos

nervous system

abnormal embryonic neuroepithelium morphology ( J:93307 )

• the neural ectoderm does not develop, resulting in the complete absence of organogenesis