Phenotypes Associated with This Genotype

Genotype
MGI:3531163

• Allelic Composition: Hmgb1^tm1Meb/Hmgb1^tm1Meb
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:55880 )

• 5 out of 29 homozygotes survived more than 24 hours after birth without glucose treatment; however all were dead by 4 weeks of age

neonatal lethality, complete penetrance ( J:55880 )

• most homozygous mice die within 24 hours after birth

growth/size/body

cachexia ( J:55880 )

• surviving homozygotes begin to waste away after 2 weeks of age

postnatal growth retardation ( J:55880 )

• surviving homozygotes stop growing around 2 weeks of age