Phenotypes Associated with This Genotype

Genotype
MGI:3531158

• Allelic Composition: Hmgb1^tm1Meb/Hmgb1^tm1Meb
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:55880 )

• homozygous mice die within 24 hours after birth

• homozygous mice can survive additional 5-25 days if given glucose intraperitoneally

behavior/neurological

lethargy ( J:55880 )

• homozygotes become lethargic after birth

homeostasis/metabolism

hypoglycemia ( J:55880 )

• blood glucose levels are normal at birth; however, hypoglycemia develops shortly after birth

decreased glycogen catabolism rate ( J:55880 )

• homozygous mice do not mobilize glycogen stored in liver and develop neonatal hypoglycemia (expression of key enzymes involved in glucose metabolism was not abolished)

respiratory system

atelectasis ( J:55880 )

• seen at birth in 8 out 10

vision/eye

eyelids open at birth ( J:55880 )

• seen in 6 out 10