Phenotypes Associated with This Genotype

Genotype
MGI:3530781

• Allelic Composition: Nrg1^tm1Cbm/Nrg1⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:100313 )

• 15 days after doxorubicin treatment to induce cardiac injury, survival is significantly lower in homozygotes (15%) than wild-type (33%)

nervous system

abnormal myelination ( J:90038 )

• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age

• more pronounced for large caliber axons than small caliber axons

abnormal nerve conduction ( J:90038 )

• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials

cardiovascular system

decreased heart weight ( J:100313 )

• 4 days after doxorubicin treatment, homozygotes show a significant decrease in heart (29% loss) and left ventricle (27% loss) weight compared to wild-type (15% for heart and 13% for left ventricle)

abnormal cardiovascular system physiology ( J:100313 )

• exhibit more severe doxorubicin-induced cardiotoxicity than wild-type, with lower left ventricular systolic pressure and left ventricular midwall fractional shortening

decreased ventricle muscle contractility ( J:100313 )

• doxorubicin-induced cardiac injury causes a higher reduction in left ventricular midwall fractional shortening than in wild-type

decreased left ventricle systolic pressure ( J:100313 )

• doxorubicin-induced cardiac injury causes a higher reduction in left ventricular systolic pressure than in wild-type

growth/size/body

weight loss ( J:100313 )

• 4 days after doxorubicin treatment, homozygotes show an increase in the loss of body weight (27%) compared to wild-type (11%)

muscle

decreased ventricle muscle contractility ( J:100313 )

• doxorubicin-induced cardiac injury causes a higher reduction in left ventricular midwall fractional shortening than in wild-type

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:100313 )

• 15 days after doxorubicin treatment to induce cardiac injury, survival is significantly lower in homozygotes (15%) than wild-type (33%)