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Phenotypes Associated with This Genotype
Genotype
MGI:3530779
Allelic
Composition		 Erbb2tm1Cbm/Erbb2+
Erbb3tm2Cbm/Erbb3+
Nrg1tm1Cbm/Nrg1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Cbm mutation (0 available); any Erbb2 mutation (59 available)
Erbb3tm2Cbm mutation (0 available); any Erbb3 mutation (47 available)
Nrg1tm1Cbm mutation (0 available); any Nrg1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelination ( J:90038 )
• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age
abnormal nerve conduction ( J:90038 )
• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory