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Phenotypes Associated with This Genotype
Genotype
MGI:3530518
Allelic
Composition
Dlc1tm1Lec/Dlc1tm1Lec
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlc1tm1Lec mutation (0 available); any Dlc1 mutation (227 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are obtained at E10.5 but are either absent or necrotic at E12.5

embryo
• at E10.5, homozygotes display reduced vascularization of the labyrinth, with defective embryonic blood vessels that contain immature fetal erythrocytes
• at E9.5, homozygotes exhibit incomplete or distorted branchial arches

cardiovascular system
• at E10.5, homozygotes display reduced vascularization of the labyrinth, with defective embryonic blood vessels that contain immature fetal erythrocytes
• at E9.5, homozygotes exhibit cardiac abnormalities of variable severity, ranging from incomplete formation of the chambers to distorted chamber architecture

nervous system
• at E9.5, homozygotes display brain abnormalities of variable severity ranging from absence of forebrain and incomplete morphogenesis of the hindbrain to an open/contorted anterior neural tube and an abnormal hindbrain with a narrow lumen and a hyperplastic neuroepithelium

cellular
• MEFs isolated from E9.5 homozygotes display reduced formation of long actin stress fibers and vinculin-rich focal adhesions

craniofacial
• at E9.5, homozygotes exhibit incomplete or distorted branchial arches


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory