mortality/aging
• only about 55% survive to 14 days after birth
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respiratory system
• E17.5 lungs had a developmental delay in maturation
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• E17.5 lungs had smaller saccules
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nervous system
• displayed a less severe callosal phenotype with the formation of Probst bundles at the midline than heterozygotes on the mixed Black Swiss background
• reduction in all three midline glial populations of the corpus callosum
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• reduction in all three midline glial populations of the corpus callosum
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