Phenotypes Associated with This Genotype

Genotype
MGI:3530491

• Allelic Composition: Nfib^tm1Rmg/Nfib^tm1Rmg
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:96006 )

• no homozygotes survived for 24 hours after birth

respiratory system

abnormal lung morphology ( J:96006 )

• observed minor surface indentations in E15.5 lungs and deep clefts or ruffles at E18.5

• higher levels of proliferation in E18.5 lung as detected by a fourfold increase in PCNA transcripts and a substantial increase in the total DNA in the lung but no differences in lung size

abnormal lung development ( J:96006 )

• E17.5 lungs were severely defective in maturation and resembled the less-mature E15.5 wildtype lungs, however morphology at E15.5 was normal indicating that lung development is arrested between E15.5 and E16.5

absent lung saccules ( J:96006 )

• E17.5 lungs lacked saccules

nervous system

abnormal hippocampus development ( J:96006 )

• a reduction in the entire hippocampal primordium at E15.5 and displayed severe disruptions in the formation of the hippocampus, with the entire CA3 region absent or severely reduced at E17.5

absent cerebellar foliation ( J:96006 )

• cerebellum appears unfoliated at E18.5

enlarged brain ventricles ( J:96006 )

• enlarged ventricles

absent corpus callosum ( J:96006 )

• exhibit agenesis of the corpus callosum

• complete absence of GFAP labeling in the indusium griseum and the glial wedge and a reduction in the midline zipper glia, indicating a loss or reduction of glial populations in the midline

abnormal pons morphology ( J:96006 )

• the basilar pons was virtually absent in the hindbrain, with only a small cap of cells remaining at E16.5 to E18.5 and the rest of the hindbrain appeared normal

abnormal hippocampus CA3 region morphology ( J:96006 )

• the entire CA3 region absent or severely reduced at E17.5

absent hippocampus CA3 region ( J:96006 )

absent dentate gyrus ( J:96006 )

• at E17.5 the dentate gyrus was absent

abnormal hippocampal fimbria morphology ( J:96006 )

• reduced fimbria in E17.5 hippocampus

abnormal glial cell morphology ( J:96006 )

• complete absence of GFAP labeling in the indusium griseum and the glial wedge and a reduction in the midline zipper glia, indicating a loss or reduction of glial populations in midline