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Phenotypes Associated with This Genotype
Genotype
MGI:3530481
Allelic
Composition
Klf10tm1Sub/Klf10tm1Sub
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf10tm1Sub mutation (0 available); any Klf10 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• the number of osteoblast, but not osteoclasts, is increased; however, bone formation is not increased
• cultured mutant osteoblasts lack the capacity to form mineralized nodules and are impaired in their ability to support osteoclast differentiation


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory