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Phenotypes Associated with This Genotype
Genotype
MGI:3530076
Allelic
Composition
Atrxtm1Rjg/Y
Tg(Nes-cre)2472Pick/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrxtm1Rjg mutation (0 available); any Atrx mutation (72 available)
Tg(Nes-cre)2472Pick mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduced postnatal survival similar to Atrx hemizygotes that are heterozygous for Foxg1tm1(cre)Skm (J:95953)
• reduced postnatal survival similar to Atrx hemizygotes that are heterozygous for Foxg1tm1(cre)Skm (J:95953)

growth/size/body
• mutants are smaller at birth (J:95953)
• mutants are smaller at birth (J:95953)

nervous system
• not as severe as in Atrx hemizygotes that are heterozygous for Foxg1tm1(cre)Skm (J:95953)
• not as severe as in Atrx hemizygotes that are heterozygous for Foxg1tm1(cre)Skm (J:95953)
• the frontal cortex is reduced in size especially in the caudal-medial cortex similar to Atrx hemizygotes that are heterozygous for Foxg1tm1(cre)Skm but the severity of loss is decreased (J:95953)
• the frontal cortex is reduced in size especially in the caudal-medial cortex similar to Atrx hemizygotes that are heterozygous for Foxg1tm1(cre)Skm but the severity of loss is decreased (J:95953)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory