Analysis Tools
endocrine/exocrine glands
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• the seminal vesicle/coagulating gland had a significantly increased wet weight because of tissue swelling
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• presence of numerous giant yellow cells that contained multiple dark stained nuclei in the hyperplastic lesions found in the peripheral space as well as in Leydig cell clusters located at inner tubular junctions of the testis
• observed a thickening of the capsule of the testis
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• seminiferous tubules were filled with vacuoles and had disrupted spermatogenic epithelium in 12 month or older mutant mice
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• cytoplasm of Leydig cells contained vacuoles and stained less uniformly with eosin than controls
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• Leydig cell hypertrophy was commonly observed within inner tubular junctions
• presence of masses of hypertrophic Leydig cells with volumes 2-3 times larger than normal in 12 month or older mutant testes but not in 2 month old mice
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• hyperplasia occurred more frequently in the peripheral space under the testicular capsule
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• significant reduction in the relative weight of the testis of 18- to 22- month old but not 3-month old mutants
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reproductive system
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• total and forward motility of caudal sperm was reduced by 60% in 18-month old mutants and 80% in 22-month old mutants but not in 3-month old males
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• the seminal vesicle/coagulating gland had a significantly increased wet weight because of tissue swelling
|
|
|
• presence of numerous giant yellow cells that contained multiple dark stained nuclei in the hyperplastic lesions found in the peripheral space as well as in Leydig cell clusters located at inner tubular junctions of the testis
• observed a thickening of the capsule of the testis
|
|
|
• seminiferous tubules were filled with vacuoles and had disrupted spermatogenic epithelium in 12 month or older mutant mice
|
|
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• cytoplasm of Leydig cells contained vacuoles and stained less uniformly with eosin than controls
|
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• Leydig cell hypertrophy was commonly observed within inner tubular junctions
• presence of masses of hypertrophic Leydig cells with volumes 2-3 times larger than normal in 12 month or older mutant testes but not in 2 month old mice
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• hyperplasia occurred more frequently in the peripheral space under the testicular capsule
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• significant reduction in the relative weight of the testis of 18- to 22- month old but not 3-month old mutants
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• significant reduction in the relative weight of the epididymis of 18- to 22-month old but not 3-month old mutants
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• overall fertility of the knockout pairs was reduced, with subsequent cross-breedings indicating an impairment in female reproductive function
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• homozygous null 17- to 18-month old males produced smaller litters when mated with wild-type females
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cellular
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• total and forward motility of caudal sperm was reduced by 60% in 18-month old mutants and 80% in 22-month old mutants but not in 3-month old males
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