Phenotypes Associated with This Genotype

Genotype
MGI:3529140

• Allelic Composition: Bag1^tm1Msd/Bag1⁺; Tg(SFTPC-RAF1-BxB)1Urr/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased lung tumor incidence ( J:95491 )

• lung tumor initiation is reduced by half at 1, 2, and 4 months of age and lung tumor area is reduced by 75% at 4 months of age

• the number of apoptotic cells in the lung adenomas is increased in double mutants compared to littermates that are wild-type for Bag1

respiratory system

decreased lung tumor incidence ( J:95491 )

• lung tumor initiation is reduced by half at 1, 2, and 4 months of age and lung tumor area is reduced by 75% at 4 months of age

• the number of apoptotic cells in the lung adenomas is increased in double mutants compared to littermates that are wild-type for Bag1