Phenotypes Associated with This Genotype

Genotype
MGI:3527935

• Allelic Composition: Abi2^tm1Pen/Abi2⁺
• Genetic Background: B6.Cg-Abi2^tm1Pen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:95254 )

• after passive avoidance training mutants have significantly shorter latencies to cross into the darkened chamber and after retraining substantially more mutants pass into the darkened chamber, 43% compared to 25% of wild-type mice

nervous system

abnormal hippocampus CA1 region morphology ( J:95254 )

• the density of apical dendritic branches is decreased in the CA1 region

abnormal hippocampus pyramidal cell morphology ( J:95254 )

• the density of spines is decreased on apical dendritic branches of layer V pyramidal cells