Phenotypes Associated with This Genotype

Genotype
MGI:3527934

• Allelic Composition: Abi2^tm1Pen/Abi2^tm1Pen
• Genetic Background: B6.Cg-Abi2^tm1Pen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:95254 )

• after passive avoidance training mutants have significantly shorter latencies to cross into the darkened chamber and after retraining substantially more mutants pass into the darkened chamber, 75% compared to 25% of wild-type mice

vision/eye

abnormal lens morphology ( J:95254 )

• at P1 the lens is grossly distorted and the posterior region is broken open due to the absence of the posterior suture

• adult mutants have small round lenses that appear to have reformed

abnormal lens capsule morphology ( J:95254 )

• the lens capsule is thicker than normal

abnormal lens development ( J:95254 )

• the anterior and posterior sutures fail to form

disorganized secondary lens fibers ( J:95254 )

• secondary lens fibers do not orient or migrate properly failing to make a 90 degree turn resulting in a convex rather than concave orientation in the equatorial region of the lens

microphthalmia ( J:95254 )

• all adult mutants have small eyes, however eyes are normal sized at E16.5 and P1 and rudimentary visual responses are intact

nervous system

abnormal corpus callosum morphology ( J:95254 )

• cortical cells are abnormally located in the corpus callosum

abnormal hippocampus morphology ( J:95254 )

abnormal hippocampus CA1 region morphology ( J:95254 )

• the density of apical dendritic branches is decreased in the CA1 region

abnormal dentate gyrus morphology ( J:95254 )

• granule cells in the dentate gyrus are less densely packed and sometimes displaced

abnormal hippocampus pyramidal cell layer ( J:95254 )

• the pyramidal layer is periodically interrupted by gaps

abnormal cerebral cortex morphology ( J:95254 )

• invaginations of layer I of the motor cortex with adjacent abnormally oriented pyramidal cells and localized heterotropic collections of disorganized neurons are seen

• regions of decreased cellularity surronded by misoriented neurons are seen in deeper layers of the motor and visual cortexes

• invaginations of layer I of the cingulate cortex were also seen in 7 out of 10 mutants

abnormal cerebral cortex pyramidal cell morphology ( J:95254 )

• the overall density of spines on basal dendrites of layer III pyramidal neurons is normal but the relative proportion of spines with mushroom-type morphology is decreased and the proportion of stubby spines is increased

• the density of spines is decreased on apical dendritic branches of layer V pyramidal cells