Phenotypes Associated with This Genotype

Genotype
MGI:3527580

• Allelic Composition: Smad2^{tm4(SMADH3)Rob}/Smad2^{tm4(SMADH3)Rob}
• Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:95374 )

• about 50% homozygous embryos die in utero or at birth

prenatal lethality, incomplete penetrance ( J:95374 )

• about 50% homozygous embryos die in utero or at birth

nervous system

abnormal forebrain development ( J:95374 )

• at E15.5-E16.5 some homozygotes displayed limited forebrain development

abnormal hindbrain development ( J:95374 )

• at E15.5-E16.5 some homozygotes displayed limited hindbrain development

holoprosencephaly ( J:95374 )

• some homozygotes display holoprosencephaly

exencephaly ( J:95374 )

• some homozygotes display exencephaly

growth/size/body

microcephaly ( J:95374 )

• some homozygotes display microcephaly