Phenotypes Associated with This Genotype

Genotype
MGI:3527208

• Allelic Composition: Foxa1^tm1Gsc/Foxa1^tm1Gsc
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:161401 )

♀ • no (0/5) detectable outgrowths at 5 weeks after orthotopic transplantation of mammary anlagen collected from E14 embryos vs 50% (3/6) of the wild-type anlagen

♀ • 0% (0/9) of the mutant anlagen vs 59% (10/17) of the wild-type form mammary ductal outgrowths at 8 weeks post-transplant

♀ • when exposed to pregnancy-associated hormones, all the mutant mammary anlagen fail (0/9) to develop, whereas 71% (5/7) of the wild-type anlagen form outgrowths with extensive alveoli

♀ • no puberty-associated mammary morphogenesis (TEBs) at 2 weeks and 4-5 weeks after renal capsule grafting of postnatal day 1 glands

integument

abnormal branching of the mammary ductal tree ( J:161401 )

♀ • no (0/5) detectable outgrowths at 5 weeks after orthotopic transplantation of mammary anlagen collected from E14 embryos vs 50% (3/6) of the wild-type anlagen

♀ • 0% (0/9) of the mutant anlagen vs 59% (10/17) of the wild-type form mammary ductal outgrowths at 8 weeks post-transplant

♀ • when exposed to pregnancy-associated hormones, all the mutant mammary anlagen fail (0/9) to develop, whereas 71% (5/7) of the wild-type anlagen form outgrowths with extensive alveoli

♀ • no puberty-associated mammary morphogenesis (TEBs) at 2 weeks and 4-5 weeks after renal capsule grafting of postnatal day 1 glands