Phenotypes Associated with This Genotype

Genotype
MGI:3526583

• Allelic Composition: Homer1^tm1Mhd/Homer1^tm1Mhd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreas physiology ( J:95212 )

• ~2.5-fold increase in spontaneous calcium influx in acinar cells compared to wild-type

• depletion of calcium stores in homozygous mutant acinar cells further increased calcium influx by only 1.7 fold compared to 3.2-fold in wild-type

• increase in the ratio of spontaneous to store-depletion current (59% compared to 26% in wild-type) in acinar cells