Phenotypes Associated with This Genotype

Genotype
MGI:3526386

• Allelic Composition: Ghr^tm2Mwat/Ghr^tm2Mwat
• Genetic Background: involves: 129X1/SvJ * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:95149 )

• in 4 and 10 month old males an increase in the relative weight of fat pad in all fat depots is seen

growth/size/body

postnatal growth retardation ( J:95149 )

• growth retardation becomes apparent after 3 weeks of age

• growth retardation is not as severe as in Ghr^tm1Jjk homozygotes but more severe than in Ghr^tm1Mwat homozygotes

hematopoietic system

small spleen ( J:95149 )

• a disproportionate decrease in spleen size compared to body size is seen

homeostasis/metabolism

hyperglycemia ( J:95149 )

• 4 and 10 month old males but not females display fasting hyperglycemia

decreased circulating insulin-like growth factor I level ( J:95149 )

• serum levels of IGF1 are less than 10% of wild-type, a greater reduction than is expected from the decrease in liver transcript levels

immune system

small spleen ( J:95149 )

• a disproportionate decrease in spleen size compared to body size is seen

liver/biliary system

decreased liver weight ( J:95149 )

• a disproportionate decrease in liver weight compared to body weight is seen

renal/urinary system

small kidney ( J:95149 )

• a disproportionate decrease in kidney size compared to body size is seen

nervous system

increased brain weight ( J:95149 )

• brain to body weight ratios are increased in mutants compared to wild-type mice