Phenotypes Associated with This Genotype

Genotype
MGI:3525573

• Allelic Composition: Gzma^tm1Simn/Gzma^tm1Simn
• Genetic Background: B6.Cg-Gzma^tm1Simn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:28773 )

N • homozygotes control growth of syngeneic tumors (s.c. inoculation of H-2b MC57G fibrosarcoma) as efficiently as wild-type mice

hematopoietic system

hematopoietic system phenotype ( J:28773 )

N • homozygotes are viable, fertile, and display normal hematopoiesis relative to wild-type mice

N • in mutant spleens, the numbers of CD4+ and CD8+ T cells, macrophages, NK cells and B cells fall within normal ranges

N • the frequencies of CD4+ and CD8+ T cells responding to H-2 alloantigens in primary mixed lymphocyte cultures (MLC) with proliferation are also within normal ranges

immune system

immune system phenotype ( J:28773 , J:92718 )

N • in vitro- and ex vivo-derived cytotoxic T cells and NK cells from mutant mice induce specific target cell membrane disruption, DNA fragmentation, and apoptosis as efficiently as wild-type cells (J:28773)

N • homozygotes control infections with lymphocytic choriomeningitis (LCM) virus and L. monocytogenes as efficiently as wild-type mice (J:28773)

N • homozygotes develop a normal contact hypersensitivity (CHS) response (based on increase in ear thickness) to trinitrophenyl (TNP) relative to wild-type mice (J:92718)