Phenotypes Associated with This Genotype

Genotype
MGI:3525354

• Allelic Composition: Tph2^Arg447/Tph2^Arg447
• Genetic Background: BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal serotonin level ( J:94745 )

• ~40% decrease in serotonin levels in the frontal cortex and striatum and ~50% and ~70% reduction in the serotonin precursor 5-hydroxytryptophan (5-HTP) synthesis in the frontal cortex and striatum, respectively, after treatment with m-hydroxybenxylhydrazine, compared to mice in a 129X1/SvJ background that are homozygous for Tph2^Pro447 and have a proline rather than an arginine at amino acid residue 447 of Tph2